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There are three primary opioid receptors: mu (μ), delta (δ), and kappa (κ).

Each of the amino acids was present in a concentration that yielded close to equimolar coupling of each amino acid.

This study demonstrates the power of mixture-based combinatorial libraries to identify distinctly different ligands for closely related receptors.

Synthetic combinatorial libraries have gained widespread acceptance for the rapid identification of new drug leads.

Screening of the same combinatorial library in separate assays selective for each of the three receptors provides not only new ligands for these receptors but yields insights into the ability of combinatorial libraries to discriminate between closely related receptors.